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Decaland Depot is an injectable anabolic preparation. The pharmacologically active substance is nandrolone. The decanoate ester provides the preparation with a duration of action of approximately 3 weeks after injection. Nandrolone is chemically related to the male hormone.
Compared to testosterone, nandrolone has a marked anabolic activity and a reduced androgenic activity. This has been demonstrated in animal bioassays and clarified by receptor binding studies. The low androgenicity of nandrolone is confirmed by clinical use.
Nandrolone decanoate has been shown to positively influence calcium metabolism and increase bone mass in osteoporosis. In women with disseminated breast carcinoma, objective regressions have been reported for many months. In addition, nandrolone has a nitrogen-sparing action.
This effect on protein metabolism has been demonstrated in metabolic studies and is used therapeutically in states where there is a protein deficiency, such as during debilitating chronic diseases and after major surgery and severe trauma.
In these conditions, nandrolone serves as a supportive adjuvant to specific treatments and dietary measures, as well as parenteral nutrition.
At the recommended doses, androgenic effects (i.e. virilization) are relatively rare. Nandrolone lacks the C17 alpha-alkyl group that is associated with the occurrence of liver dysfunction and cholestasis.
Nandrolone decanoate is slowly released from the injection site into the blood with a half-life of 6 days. In the blood, the ester is rapidly hydrolyzed to nandrolone with a half-life of one or less.
The half-life for the combined process of hydrolysis of nandrolone decanoate and the distribution and elimination of nandrolone is 4.3 hours.
Nandrolone is metabolized by the liver.
The substances 19- norandrosterone, 19- noretocholanolone and 19- norepiandrosterone have been identified as metabolites in urine. It is not known whether these metabolites have any pharmacological action.
Therapeutic Indications:
Protein anabolism stimulant.
Osteoporosis.
For the palliative treatment of selected cases of disseminated breast carcinoma in women.
As an adjuvant in specific therapies and dietary measures in pathological states characterized by a negative nitrogen balance.
Note: For optimal therapeutic effect, it is necessary to administer adequate amounts of vitamins, minerals and proteins in a high-calorie diet.
Side and Adverse Reactions:
High doses, prolonged treatment and/or too frequent administration may cause:
Virilization manifesting itself in sensitive women as hoarseness, acne, hirsutism and increased libido; in boys before puberty, as an increase in the frequency of erections and phallic enlargement; and in girls as an increase in pubic hair and clitoral hypertrophy. Hoarseness may be the first symptom of a vocal change that can lead to sometimes irreversible deepening of the voice.
Amenorrhea.
Inhibition of spermatogenesis.
Premature epiphyseal closure.
Fluid retention.
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